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Invitrogen™ ERK5 Monoclonal Antibody (OTI3D4)
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Catalog No. PIMA525351
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100 μL
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Catalog No. Quantity
PIMA525351 100 μL
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Catalog No. PIMA525351 Supplier Invitrogen™ Supplier No. MA525351
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Description

Mouse Monoclonal Antibody

ERK5 Monoclonal Antibody for Flow, ICC/IF, Western Blot

MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK7 is activated by mitogen-activated protein kinase 5 (MAP2K5/MEK5) and is involved in downstream signaling processes of various receptors. In response to extracelluar signals, MAPK7 translocates to the cell nucleus where it regulates gene expression by phosphorylating and activating different transcription factors. Gene deletion of MAPK7 in mice results in defective blood vessel and cardiac development leading to embryonic lethality. MAPK7 has been shown to be critical for endothelial function and maintenance of blood vessel integrity. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. ERK5 is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ERK5
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone OTI3D4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 1% BSA and 0.02% sodium azide; pH 7.3
Gene MAPK7
Gene Accession No. Q13164
Gene Alias Big MAP kinase 1; BMK1; BMK-1; BMK1 kinase; BNhp-1; BNhp1 kinase; ERK4; ERK5; ERK-5; Erk5-T; extracellular signal regulated kinase 5; extracellular signal-regulated kinase 5; extracellular-signal-regulated kinase 5; MAP kinase 7; MAPK 7; Mapk7; mitogen activated protein kinase 7; mitogen-activated protein kinase 7; PRKM7
Gene Symbols MAPK7
Host Species Mouse
Immunogen Full length human recombinant protein of MAPK7 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5598
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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