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Invitrogen™ ERLIN2 Monoclonal Antibody (C2), Invitrogen™

Catalog No. PIMA543835
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100 μL
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PIMA543835 20 μL
PIMA543834 100 μL
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Catalog No. PIMA543835 Supplier Invitrogen™ Supplier No. MA543835
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Description

Mouse Monoclonal Antibody

ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1, 4, 5-trisphosphate receptors (IP3Rs) such as ITPR1. It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ERLIN2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone C2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene ERLIN2
Gene Accession No. O94905
Gene Alias BC036333; C87251; C8orf2; EMBL:AAI68668.1, ECO:0000312; EMBL:AAI68668.1}; endoplasmic reticulum lipid raft-associated protein 2; endoplasmic reticulum lipid raft-associated protein 2 {ECO:0000250; ER lipid raft associated 2; Erlin2; erlin-2; erlin-2 {ECO:0000250; erlin2 {ECO:0000312; HGNC:1356; MGC87072; NET32; RGD:1309010}; RGD1309010; SPFH domain family, member 2; SPFH domain-containing protein 2; SPFH domain-containing protein 2 {ECO:0000250; Spfh2; SPG18; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 {ECO:0000250; UniProtKB:Q8BFZ9, ECO:0000312; UniProtKB:Q8BFZ9}; UNQ2441; UNQ2441/PRO5003/PRO9924
Gene Symbols ERLIN2
Host Species Mouse
Immunogen Pro47-Asn339 (Accession O94905), with N-terminal His Tag.
Purification Method Protein A/G
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11160
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a λ
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