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Invitrogen™ ERLIN2 Polyclonal Antibody
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Catalog No. PIPA551669
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100 μL
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PIPA551669 100 μL
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Catalog No. PIPA551669 Supplier Invitrogen™ Supplier No. PA551669
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KTKLLIAAQK QKVVEKEAET ERKKALIEAE KVAQVAEITY GQKVMEKETE KKISEIEDAA FLAREKAKAD AECYTAMKIA EANKLKLTPE YLQLMKYKAI ASNSKIYFGK DIPNMFMDSA GSVSKQFEGL ADKLSFGLED EPLETATK Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.

ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1, 4, 5-trisphosphate receptors (IP3Rs) such as ITPR1. It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ERLIN2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ERLIN2
Gene Accession No. B5DEH2, O94905, Q8BFZ9
Gene Alias BC036333; C87251; C8orf2; EMBL:AAI68668.1, ECO:0000312; EMBL:AAI68668.1}; endoplasmic reticulum lipid raft-associated protein 2; endoplasmic reticulum lipid raft-associated protein 2 {ECO:0000250; ER lipid raft associated 2; Erlin2; erlin-2; erlin-2 {ECO:0000250; erlin2 {ECO:0000312; HGNC:1356; MGC87072; NET32; RGD:1309010}; RGD1309010; SPFH domain family, member 2; SPFH domain-containing protein 2; SPFH domain-containing protein 2 {ECO:0000250; Spfh2; SPG18; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 {ECO:0000250; UniProtKB:Q8BFZ9, ECO:0000312; UniProtKB:Q8BFZ9}; UNQ2441; UNQ2441/PRO5003/PRO9924
Gene Symbols ERLIN2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ERLIN2. Recombinant protein control fragment (Product #RP-95924).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11160, 244373, 290823
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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