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ERLIN2 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA517103
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PIPA517103 100 μL
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Catalog No. PIPA517103 Supplier Thermo Scientific Supplier No. PA517103

Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody.

ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1, 4, 5-trisphosphate receptors (IP3Rs) such as ITPR1. It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ERLIN2
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene ERLIN2
Gene Accession No. O94905, Q8BFZ9
Gene Alias BC036333; C87251; C8orf2; EMBL:AAI68668.1, ECO:0000312; EMBL:AAI68668.1}; endoplasmic reticulum lipid raft-associated protein 2; endoplasmic reticulum lipid raft-associated protein 2 {ECO:0000250; ER lipid raft associated 2; Erlin2; erlin-2; erlin-2 {ECO:0000250; erlin2 {ECO:0000312; HGNC:1356; MGC87072; NET32; RGD:1309010}; RGD1309010; SPFH domain family, member 2; SPFH domain-containing protein 2; SPFH domain-containing protein 2 {ECO:0000250; Spfh2; SPG18; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 {ECO:0000250; UniProtKB:Q8BFZ9, ECO:0000312; UniProtKB:Q8BFZ9}; UNQ2441; UNQ2441/PRO5003/PRO9924
Gene Symbols ERLIN2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues surrounding Gln315 of mouse erlin-2
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11160, 244373
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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