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Invitrogen™ ERLIN2 Recombinant Rabbit Monoclonal Antibody (9T3M5)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA542625
Description
Positive test controls include: 293T, PC-3, OVCAR3, C2C12. The target is usually found in the following locations: Endoplasmic reticulum membrane, Single-pass type II membrane protein. Immunogen sequence: HLMLPFITSY KSVQTTLQTD EVKNVPCGTS GGVMIYFDRI EVVNFLVPNA VYDIVKNYTA DYDKALIFNK IHHELNQFCS VHTLQEVYIE LFDQIDENLK L.
ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1, 4, 5-trisphosphate receptors (IP3Rs) such as ITPR1. It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.
Specifications
ERLIN2 | |
Recombinant Monoclonal | |
1.2 mg/mL | |
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3 | |
B5DEH2, O94905, Q8BFZ9 | |
ERLIN2 | |
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Erlin-2 (O94905). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
ELISA, Immunohistochemistry (Paraffin), Western Blot | |
9T3M5 | |
Unconjugated | |
ERLIN2 | |
BC036333; C87251; C8orf2; EMBL:AAI68668.1, ECO:0000312; EMBL:AAI68668.1}; endoplasmic reticulum lipid raft-associated protein 2; endoplasmic reticulum lipid raft-associated protein 2 {ECO:0000250; ER lipid raft associated 2; Erlin2; erlin-2; erlin-2 {ECO:0000250; erlin2 {ECO:0000312; HGNC:1356; MGC87072; NET32; RGD:1309010}; RGD1309010; SPFH domain family, member 2; SPFH domain-containing protein 2; SPFH domain-containing protein 2 {ECO:0000250; Spfh2; SPG18; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 {ECO:0000250; UniProtKB:Q8BFZ9, ECO:0000312; UniProtKB:Q8BFZ9}; UNQ2441; UNQ2441/PRO5003/PRO9924 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
11160, 244373, 290823 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Safety and Handling
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