Invitrogen™ ERLIN2 Recombinant Rabbit Monoclonal Antibody (9T3M5)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542625

Catalog No. PIMA542625

Description

Positive test controls include: 293T, PC-3, OVCAR3, C2C12. The target is usually found in the following locations: Endoplasmic reticulum membrane, Single-pass type II membrane protein. Immunogen sequence: HLMLPFITSY KSVQTTLQTD EVKNVPCGTS GGVMIYFDRI EVVNFLVPNA VYDIVKNYTA DYDKALIFNK IHHELNQFCS VHTLQEVYIE LFDQIDENLK L.

ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1, 4, 5-trisphosphate receptors (IP3Rs) such as ITPR1. It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.

Specifications

• Antigen: ERLIN2
• Classification: Recombinant Monoclonal
• Concentration: 1.2 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: B5DEH2, O94905, Q8BFZ9
• Gene Symbols: ERLIN2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Erlin-2 (O94905).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 9T3M5
• Conjugate: Unconjugated
• Gene: ERLIN2
• Gene Alias: BC036333; C87251; C8orf2; EMBL:AAI68668.1, ECO:0000312; EMBL:AAI68668.1}; endoplasmic reticulum lipid raft-associated protein 2; endoplasmic reticulum lipid raft-associated protein 2 {ECO:0000250; ER lipid raft associated 2; Erlin2; erlin-2; erlin-2 {ECO:0000250; erlin2 {ECO:0000312; HGNC:1356; MGC87072; NET32; RGD:1309010}; RGD1309010; SPFH domain family, member 2; SPFH domain-containing protein 2; SPFH domain-containing protein 2 {ECO:0000250; Spfh2; SPG18; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 {ECO:0000250; UniProtKB:Q8BFZ9, ECO:0000312; UniProtKB:Q8BFZ9}; UNQ2441; UNQ2441/PRO5003/PRO9924
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11160, 244373, 290823
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov