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Tocris Bioscience™ Erlotinib Hydrochloride
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Catalog No. 719450
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50 mg
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71-945-0 50 mg
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Catalog No. 71-945-0 Supplier Tocris Bioscience™ Supplier No. 7194/50
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Description

Potent, reversible EGFR tyrosine kinase inhibitor

Erlotinib hydrochloride is a reversible, potent EGFR tyrosine kinase inhibitor (IC50 = 2 nM); it reduces EGFR autophosphorylation in intact tumor cells (IC50 = 20 nM). Erlotinib is selective for cell lines showing PC-9 and H3255 mutations (IC50 values are 7 and 12 nM, respectively, sparing wild-type and T790 mutant EGFR. Erlotinib shows antiproliferative effects in cancer cell lines in vitro and promotes differentiation of urothelial organoids. Orally bioavailable.

Specifications

Chemical Name or Material N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
CAS 183319-69-9
Quantity 50 mg
Target EGF Receptor Inhibitors
Molecular Formula C22H23N3O4.HCl
Purity 0.98
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