Invitrogen™ ERMAP Monoclonal Antibody (767505)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524371

Catalog No. PIMA524371

Description

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Erythroblast membrane-associated protein (ERMAP) is a gene situated on chromosome 1p34.2, encoding a protein primarily associated with erythroblast cells. ERMAP is expressed in erythroid lineage cells and plays a crucial role as an adhesion molecule, involved in the maturation and stability of the erythrocyte membrane. This protein is associated with the Scianna blood group system, and variations within the ERMAP gene lead to different antigenic expressions which are important in transfusion medicine. ERMAP is also significant in mediating cell-cell adhesion processes essential for erythropoiesis, where it facilitates receptor-ligand interactions in hematopoietic stem cells. Mutations or polymorphisms in ERMAP can result in altered blood group antigens, impacting blood transfusion compatibility and potentially leading to hemolytic reactions. Given its distinct role in erythrocyte formation, ERMAP is a subject of interest for further research into blood-related disorders and their genetic underpinnings.

Specifications

• Antigen: ERMAP
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q96PL5
• Gene Symbols: ERMAP
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human ERMAP His30-Ala155.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry
• Clone: 767505
• Conjugate: Unconjugated
• Gene: ERMAP
• Gene Alias: AA409279; AI666418; BTN5; ERMAP; erythroblast membrane associated protein (Scianna blood group); erythroblast membrane-associated protein; erythroblast membrane-associated protein (Scianna blood group); erythroid membrane-associated protein; hERMAP; MGC118810; MGC118811; PRO2801; Radin blood group; Radin blood group (Rd); radin blood group antigen; RD; RDMGC118812; SC; Scianna blood group; Scianna blood group (Sc); scianna blood group antigen; SCMGC118813
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 114625
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized