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Invitrogen™ ERMAP Polyclonal Antibody
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Catalog No. PIPA587889
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100 μL
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PIPA587889 100 μL
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Catalog No. PIPA587889 Supplier Invitrogen™ Supplier No. PA587889
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HAGDAGKFHV ALLGGTAELL CPLSLWPGTV PKEVRWLRSP FPQRSQAVHI FRDGKDQDED LMPEYKGRTV LVRDAQEGSV TLQILDVRLE DQGSYRCLIQ VGNLSKEDTV ILQVAAPSVG SLSPSA; Positive Samples: BT-474, A-549, K-562, Mouse liver; Cellular Location: Cell membrane, Cytoplasm, Single-pass type I membrane protein.

Erythroblast membrane-associated protein (ERMAP) is a gene situated on chromosome 1p34.2, encoding a protein primarily associated with erythroblast cells. ERMAP is expressed in erythroid lineage cells and plays a crucial role as an adhesion molecule, involved in the maturation and stability of the erythrocyte membrane. This protein is associated with the Scianna blood group system, and variations within the ERMAP gene lead to different antigenic expressions which are important in transfusion medicine. ERMAP is also significant in mediating cell-cell adhesion processes essential for erythropoiesis, where it facilitates receptor-ligand interactions in hematopoietic stem cells. Mutations or polymorphisms in ERMAP can result in altered blood group antigens, impacting blood transfusion compatibility and potentially leading to hemolytic reactions. Given its distinct role in erythrocyte formation, ERMAP is a subject of interest for further research into blood-related disorders and their genetic underpinnings.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ERMAP
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.8 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ERMAP
Gene Accession No. Q96PL5, Q9JLN5
Gene Alias AA409279; AI666418; BTN5; ERMAP; erythroblast membrane associated protein (Scianna blood group); erythroblast membrane-associated protein; erythroblast membrane-associated protein (Scianna blood group); erythroid membrane-associated protein; hERMAP; MGC118810; MGC118811; PRO2801; Radin blood group; Radin blood group (Rd); radin blood group antigen; RD; RDMGC118812; SC; Scianna blood group; Scianna blood group (Sc); scianna blood group antigen; SCMGC118813
Gene Symbols ERMAP
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 30-155 of human ERMAP (NP_0610082).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114625, 27028
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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