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Invitrogen™ ERN1/ERN2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115434

Catalog No. PIPA5115434


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Description

Description

Antibody detects endogenous levels of total IRE1.

ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) is a Protein Coding gene. Diseases associated with ERN1 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 5 and Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus. Among its related pathways are Spinocerebellar ataxia and Photodynamic therapy-induced unfolded protein response. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is ERN2. This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017].
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ERN1/ERN2
Polyclonal
Unconjugated
Ern1
9030414B18Rik; AI225830; C85377; endoplasmic reticulum (ER) to nucleus signalling 1; endoplasmic reticulum (ER) to nucleus signalling 2; endoplasmic reticulum to nucleus signaling 1; endoplasmic reticulum to nucleus signaling 2; endoplasmic reticulum to nucleus signalling 2; endoplasmic reticulum-to-nucleus signaling 1; Endoplasmic reticulum-to-nucleus signaling 2; Endoribonuclease; ER to nucleus signalling 1; ER to nucleus signalling 2; ERN1; ERN2; hIRE1p; hIRE2p; inositol-requiring 1; inositol-requiring 1 (Yeast homologue); inositol-requiring 1 alpha; inositol-requiring 1 beta; inositol-requiring enzyme 1; inositol-requiring protein 1; Inositol-requiring protein 2; Ire1; IRE1 beta; IRE1, S. cerevisiae, homolog of; Ire1a; Ire1alpha; ire1-alpha; IRE1b; Ire1-beta; Ire1p; Ire2; IRE2p; mIre1; protein kinase/endoribonuclease; RGD1559716; Serine/threonine-protein kinase; Serine/threonine-protein kinase/endoribonuclease IRE1; serine/threonine-protein kinase/endoribonuclease IRE2
Rabbit
Affinity chromatography
RUO
10595, 2081, 26918, 365363, 498013, 78943
-20°C
Liquid
Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide
O75460, Q76MJ5, Q9EQY0, Q9Z2E3
Ern1, Ern2
A synthesized peptide derived from human ERN1(Accession O75460), corresponding to amino acid residues P603-V653.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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