Invitrogen™ ERN1/ERN2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115434

Catalog No. PIPA5115434

Description

Antibody detects endogenous levels of total IRE1.

ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) is a Protein Coding gene. Diseases associated with ERN1 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 5 and Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus. Among its related pathways are Spinocerebellar ataxia and Photodynamic therapy-induced unfolded protein response. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is ERN2. This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017].

Specifications

• Antigen: ERN1/ERN2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ern1
• Gene Alias: 9030414B18Rik; AI225830; C85377; endoplasmic reticulum (ER) to nucleus signalling 1; endoplasmic reticulum (ER) to nucleus signalling 2; endoplasmic reticulum to nucleus signaling 1; endoplasmic reticulum to nucleus signaling 2; endoplasmic reticulum to nucleus signalling 2; endoplasmic reticulum-to-nucleus signaling 1; Endoplasmic reticulum-to-nucleus signaling 2; Endoribonuclease; ER to nucleus signalling 1; ER to nucleus signalling 2; ERN1; ERN2; hIRE1p; hIRE2p; inositol-requiring 1; inositol-requiring 1 (Yeast homologue); inositol-requiring 1 alpha; inositol-requiring 1 beta; inositol-requiring enzyme 1; inositol-requiring protein 1; Inositol-requiring protein 2; Ire1; IRE1 beta; IRE1, S. cerevisiae, homolog of; Ire1a; Ire1alpha; ire1-alpha; IRE1b; Ire1-beta; Ire1p; Ire2; IRE2p; mIre1; protein kinase/endoribonuclease; RGD1559716; Serine/threonine-protein kinase; Serine/threonine-protein kinase/endoribonuclease IRE1; serine/threonine-protein kinase/endoribonuclease IRE2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10595, 2081, 26918, 365363, 498013, 78943
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O75460, Q76MJ5, Q9EQY0, Q9Z2E3
• Gene Symbols: Ern1, Ern2
• Immunogen: A synthesized peptide derived from human ERN1(Accession O75460), corresponding to amino acid residues P603-V653.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov