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ERN2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501987487
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100 μL
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50-198-7487 100 μL
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Catalog No. 50-198-7487 Supplier Bioss Supplier No. BS6771R
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Rabbit Polyclonal Antibody

ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.

Specifications

Antigen ERN2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene ERN2
Gene Accession No. Q76MJ5
Gene Alias endoplasmic reticulum (ER) to nucleus signalling 2; endoplasmic reticulum to nucleus signaling 2; endoplasmic reticulum to nucleus signalling 2; Endoplasmic reticulum-to-nucleus signaling 2; Endoribonuclease; ER to nucleus signalling 2; Ern1; ERN2; hIRE2p; inositol-requiring 1 (Yeast homologue); inositol-requiring 1 beta; Inositol-requiring protein 2; Ire1; IRE1 beta; IRE1, S. cerevisiae, homolog of; IRE1b; Ire1-beta; IRE2; IRE2p; mIre1; Serine/threonine-protein kinase; Serine/threonine-protein kinase/endoribonuclease IRE2
Gene Symbols ERN2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human ERN2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10595
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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