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Invitrogen™ ERO1L Polyclonal Antibody
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Catalog No. PIPA529535
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100 μL
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PIPA529535 100 μL
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Catalog No. PIPA529535 Supplier Invitrogen™ Supplier No. PA529535
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HCT116, MCF-7, mouse stomach. Predicted reactivity: Rat (90%), Pig (96%), Rhesus Monkey (99%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ERO1L (endoplasmic oxidoreductin-1-like protein) is localized in ER membrane as peripheral membrane protein on the lumenal side. Its association with ERP44 is essential for its retention in the ER and is unique in coupling oxygen reduction to de novo disulfides formation. The ERO1L enzyme is broadly distributed at low levels in several tissues with highest levels in the upper digestive tract and is stimulated by hypoxia via HIF-signaling. ERO1L generally exists as monomer, but has the ability to function as monomer or homodimer and interacts with PDILT. After translation, ERO1L gets n-glycosylated and the disulfide bonds constitute the redox-active center whereby the Cys-94/Cys-99 disulfide bond accepts an electron from P4HB followed by funneling the same to the active site disulfide Cys-394/Cys-397. ERO1L acts by oxidizing directly to P4HB/PDI isomerase through direct disulfide exchange and associates with ERP44. ERO1L is implicated in immunoglobulin folding, oxidative stress, release of unfolded cholera toxin from reduced P4HB/PDI upon Vibrio cholerae infection, and plays a key role in ER stress-induced CHOP-dependent apoptosis through inositol 1,4,5-trisphosphate receptor IP3R1 activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ERO1L
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.95 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene ERO1A
Gene Accession No. Q96HE7
Gene Alias Endoplasmic oxidoreductin-1-like protein; endoplasmic reticulum oxidation 1; endoplasmic reticulum oxidoreductase 1 alpha; endoplasmic reticulum oxidoreductase alpha; Endoplasmic reticulum oxidoreductin-1-like protein; ero1; ERO1A; Ero1alpha; ERO1-alpha; ERO1L; ERO1-L; ERO1LA; ERO1-L-alpha; ERO1-like; ERO1-like (S. cerevisiae); ERO1-like protein alpha; Giig11; Global ischemia-induced protein 11; oxidoreductin-1-L-alpha; UNQ434/PRO865
Gene Symbols ERO1A
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human ERO1L. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 30001, 423585
Target Species Chicken, Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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