Invitrogen™ ESCO1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA560000

Catalog No. PIPA560000

Description

Immunogen sequence: ERAPENCHLA NEIKPSDPPL DNQMKHSFDS ASNKNFSQCL ESKLENSPVE NVTAASTLLS QAKIDTGENK FPGSAPQQHS ILSNQTSKSS DNRETPRNHS LPKCNSHLEI Highest antigen sequence identity to the following orthologs: Mouse - 59%, Rat - 64%.

EFO1 (Establishment factor-like protein 1), also known as ESCO1 (establishment of cohesion 1 homolog1) or ESO1, is a member of the acetyltransferase family (GCN5 subfamily). It is a ubiquitously expressed nuclear protein that plays an important role in sister chromatid cohesion. At its C-terminus, EFO1 contains an H2C2 zinc finger motif and an acetyltransferase domain that exhibits acetyltransferase activity in vivo. Its N-terminus, containing two domains that are similar o alpha- and beta-type linker histone proteins, is essential for EFO1 association with chromosomes. EFO1 is responsible for coupling cohesion and DNA replication processes thereby ensuring proper pairing of sister chromatids. EFO1 is phosphorylated during mitosis and this may act to regulate EFO1 activity. Due to alternative splicing events, three EFO1 isoforms exist.

Specifications

• Antigen: ESCO1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ESCO1
• Gene Alias: A930014I12Rik; CTF; CTF7 homolog 1; ECO1; ECO1 homolog 1; EFO1; EFO1p; ESCO1; ESO1; ESO1 homolog 1; establishment factor-like protein 1; Establishment of cohesion 1 homolog 1; establishment of cohesion 1 homolog 1 (S. cerevisiae); establishment of sister chromatid cohesion N-acetyltransferase 1; establisment of cohesion 1 homolog 1; hEFO1; Kiaa1911; N-acetyltransferase ESCO1; N-acetyltransferase ESCO1 variant 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114799
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5FWF5
• Gene Symbols: ESCO1
• Immunogen: Recombinant protein corresponding to Human ESCO1. Recombinant protein control fragment (Product #RP-98281).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov