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Invitrogen™ ESCO1 Polyclonal Antibody
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Catalog No. PIPA560000
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100 μL
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PIPA560000 100 μL
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Catalog No. PIPA560000 Supplier Invitrogen™ Supplier No. PA560000
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ERAPENCHLA NEIKPSDPPL DNQMKHSFDS ASNKNFSQCL ESKLENSPVE NVTAASTLLS QAKIDTGENK FPGSAPQQHS ILSNQTSKSS DNRETPRNHS LPKCNSHLEI Highest antigen sequence identity to the following orthologs: Mouse - 59%, Rat - 64%.

EFO1 (Establishment factor-like protein 1), also known as ESCO1 (establishment of cohesion 1 homolog1) or ESO1, is a member of the acetyltransferase family (GCN5 subfamily). It is a ubiquitously expressed nuclear protein that plays an important role in sister chromatid cohesion. At its C-terminus, EFO1 contains an H2C2 zinc finger motif and an acetyltransferase domain that exhibits acetyltransferase activity in vivo. Its N-terminus, containing two domains that are similar o alpha- and beta-type linker histone proteins, is essential for EFO1 association with chromosomes. EFO1 is responsible for coupling cohesion and DNA replication processes thereby ensuring proper pairing of sister chromatids. EFO1 is phosphorylated during mitosis and this may act to regulate EFO1 activity. Due to alternative splicing events, three EFO1 isoforms exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ESCO1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ESCO1
Gene Accession No. Q5FWF5
Gene Alias A930014I12Rik; CTF; CTF7 homolog 1; ECO1; ECO1 homolog 1; EFO1; EFO1p; ESCO1; ESO1; ESO1 homolog 1; establishment factor-like protein 1; Establishment of cohesion 1 homolog 1; establishment of cohesion 1 homolog 1 (S. cerevisiae); establishment of sister chromatid cohesion N-acetyltransferase 1; establisment of cohesion 1 homolog 1; hEFO1; Kiaa1911; N-acetyltransferase ESCO1; N-acetyltransferase ESCO1 variant 2
Gene Symbols ESCO1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ESCO1. Recombinant protein control fragment (Product #RP-98281).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114799
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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