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Invitrogen™ ESCO1 Polyclonal Antibody
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Catalog No. PIPA5103942
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PIPA5103942 100 μL
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Catalog No. PIPA5103942 Supplier Invitrogen™ Supplier No. PA5103942
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ESCO1.

EFO1 (Establishment factor-like protein 1), also known as ESCO1 (establishment of cohesion 1 homolog1) or ESO1, is a member of the acetyltransferase family (GCN5 subfamily). It is a ubiquitously expressed nuclear protein that plays an important role in sister chromatid cohesion. At its C-terminus, EFO1 contains an H2C2 zinc finger motif and an acetyltransferase domain that exhibits acetyltransferase activity in vivo. Its N-terminus, containing two domains that are similar o alpha- and beta-type linker histone proteins, is essential for EFO1 association with chromosomes. EFO1 is responsible for coupling cohesion and DNA replication processes thereby ensuring proper pairing of sister chromatids. EFO1 is phosphorylated during mitosis and this may act to regulate EFO1 activity. Due to alternative splicing events, three EFO1 isoforms exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ESCO1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ESCO1
Gene Accession No. Q5FWF5, Q69Z69
Gene Alias A930014I12Rik; CTF; CTF7 homolog 1; ECO1; ECO1 homolog 1; EFO1; EFO1p; ESCO1; ESO1; ESO1 homolog 1; establishment factor-like protein 1; Establishment of cohesion 1 homolog 1; establishment of cohesion 1 homolog 1 (S. cerevisiae); establishment of sister chromatid cohesion N-acetyltransferase 1; establisment of cohesion 1 homolog 1; hEFO1; Kiaa1911; N-acetyltransferase ESCO1; N-acetyltransferase ESCO1 variant 2
Gene Symbols ESCO1
Host Species Rabbit
Immunogen A synthesized peptide derived from human ESCO1(Accession Q5FWF5), corresponding to amino acid residues F547-A597.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114799, 77805
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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