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Tocris Bioscience™ ESI 1

Catalog No. 881150
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88-115-0 50 mg
88-111-0 10 mg
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Catalog No. 88-115-0 Supplier Tocris Bioscience™ Supplier No. 8811/50
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Description

Selective HDAC3 inhibitor; also myelination inducer

ESI 1 (epigenetic silencing inhibitor 1; also called PT3) is an HDAC3 inhibitor (IC50 = 250 nM). ESI 1 exhibits high selectivity for HDAC3 over HDAC1, HDAC6, and HDAC8. Also, ESI 1 promotes remyelination in demyelinated animal models and enables de novo myelinogenesis on regenerated CNS axons. In vivo, ESI 1 enhances long-term memory in mouse model of novel object recognition. ESI 1 triggers nuclear condensate formation of lipid-metabolic regulators SREBP1/2, concentrating transcriptional co-activators to drive lipid/cholesterol biosynthesis. ESI 1 is orally bioavailable and blood-brain-barrier penetrant.

Specifications

Chemical Name or Material N-(2-Aminophenyl)-5-[(phenylmethyl)amino]-2-pyrazinecarboxamide dihydrochloride
Quantity 50 mg
Target Class I Histone Deacetylases Inhibitors
Molecular Formula C18H17N5O.2HCl
Purity 98%
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