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ESPL1 (phospho S1126) Rabbit anti-Human, Polyclonal , Abnova™

Catalog No. 89956751 Shop All Abnova Corporation Products
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89-956-751 100 μL
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Catalog No. 89-956-751 Supplier Abnova Corporation Supplier No. PAB29597
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Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ESPL1.

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 604359) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM]

Specifications

Antigen ESPL1 (phospho S1126)
Applications Immunofluorescence, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ESPL1.
Dilution Immunofluorescence (1:20-1:100) Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.
Formulation In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Gene Alias ESP1/FLJ46492/KIAA0165/SEPARASE/SEPARIN
Gene Symbols ESPL1
Host Species Rabbit
Immunogen A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S1126 of human ESPL1.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9700
Test Specificity ESPL1 (phospho S1126) polyclonal antibody detects endogenous levels of human ESPL1 only when phosphorylated at serine 1126.
Target Species Human
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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