ESR1 Mouse anti-Canine, Human, Mouse, Clone: OTI3G2, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF807239

Catalog No. 50-166-8171

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

Specifications

• Antigen: ESR1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ESR1
• Gene Alias: ER, ESR, ESRA, ESTRR, Era, NR3A1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13982, 2099, 403640
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI3G2
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P03372, P19785
• Gene Symbols: ESR1
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-310 of human ESR1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Canine, Human, Mouse
• Product Type: Antibody
• Isotype: IgG2a