ESRRB Monoclonal Antibody (OTI12H2), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA805749

Catalog No. 50-168-0825

Description

ESRRB (steroid hormone receptor ERR2) plays a role in maintaice of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation ESRRB interacts with KDM1A by directly binding to enhancer sites of ELF5 and EOMES and activates their transcription leading to self-renewal of trophoblast stem cells. ESSRB also regulates expression of multiple rod-specific genes and is required for survial of this cell type. Defects in the gene can cause deafness, autosomal recessive, 35 (DFNB35).

Specifications

• Antigen: ESRRB
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O95718
• Gene Symbols: ESRRB
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-252 of human ESRRB produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot
• Clone: OTI12H2
• Conjugate: Unconjugated
• Gene: ESRRB
• Gene Alias: DFNB35, ERR2, ERRb, ESRL2, NR3B2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2103
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid