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Invitrogen™ ESRRB Polyclonal Antibody
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Catalog No. PA1315
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100 μg
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Catalog No. Quantity
PA1-315 100 μg
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Catalog No. PA1-315 Supplier Invitrogen™ Supplier No. PA1315
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Description

Rabbit Polyclonal Antibody

PA1-315 detects ERR2 from mouse and rat kidney extracts. PA1-315 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects an ~48 kDa protein representing ERR2 from rat kidney extract. The PA1-315 immunogen is a synthetic peptide corresponding to residues D(376) Y E L S Q R H E E P R R(388) of mouse ERR2. This peptide (Cat. # PEP-251) is available for use in neutralization and control experiments.

ESRRB (steroid hormone receptor ERR2) plays a role in maintenance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation ESRRB interacts with KDM1A by directly binding to enhancer sites of ELF5 and EOMES and activates their transcription leading to self-renewal of trophoblast stem cells. ESSRB also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Defects in the gene can cause deafness, autosomal recessive, 35 (DFNB35).
TRUSTED_SUSTAINABILITY

Specifications

Antigen ESRRB
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene ESRRB
Gene Accession No. P11475, Q61539
Gene Alias DFNB35; ERR beta-2; ERR2; Err-2; ERRb; ERRB2; ERRbeta; ERR-beta; ERRbeta-2; ESRL2; ESRRB; estrogen receptor related 2; estrogen receptor-like 2; estrogen related receptor beta; estrogen related receptor, beta; estrogen-related nuclear receptor beta; estrogen-related receptor beta; estrogen-related receptor, beta; Estrrb; NR3B2; nuclear receptor ERRB2; nuclear receptor subfamily 3 group B member 2; orphan nuclear receptor; steroid hormone receptor ERR2
Gene Symbols ESRRB
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues D(376) Y E L S Q R H E E P R R(388) of mouse ERR2.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26380, 299210
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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