Invitrogen™ ESRRB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1315

Catalog No. PA1-315

Description

PA1-315 detects ERR2 from mouse and rat kidney extracts. PA1-315 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects an ~48 kDa protein representing ERR2 from rat kidney extract. The PA1-315 immunogen is a synthetic peptide corresponding to residues D(376) Y E L S Q R H E E P R R(388) of mouse ERR2. This peptide (Cat. # PEP-251) is available for use in neutralization and control experiments.

ESRRB (steroid hormone receptor ERR2) plays a role in maintenance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation ESRRB interacts with KDM1A by directly binding to enhancer sites of ELF5 and EOMES and activates their transcription leading to self-renewal of trophoblast stem cells. ESSRB also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Defects in the gene can cause deafness, autosomal recessive, 35 (DFNB35).

Specifications

• Antigen: ESRRB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ESRRB
• Gene Alias: DFNB35; ERR beta-2; ERR2; Err-2; ERRb; ERRB2; ERRbeta; ERR-beta; ERRbeta-2; ESRL2; ESRRB; estrogen receptor related 2; estrogen receptor-like 2; estrogen related receptor beta; estrogen related receptor, beta; estrogen-related nuclear receptor beta; estrogen-related receptor beta; estrogen-related receptor, beta; Estrrb; NR3B2; nuclear receptor ERRB2; nuclear receptor subfamily 3 group B member 2; orphan nuclear receptor; steroid hormone receptor ERR2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26380, 299210
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P11475, Q61539
• Gene Symbols: ESRRB
• Immunogen: Synthetic peptide corresponding to residues D(376) Y E L S Q R H E E P R R(388) of mouse ERR2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG