Invitrogen™ ESRRB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA533522

Catalog No. PIPA533522

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Hamster, Panda, Horse (100%) Mouse, Rat, Elephant, Bovine, Bat, Rabbit, Pig (93%) Dog (86%).

ESRRB (steroid hormone receptor ERR2) plays a role in maintenance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation ESRRB interacts with KDM1A by directly binding to enhancer sites of ELF5 and EOMES and activates their transcription leading to self-renewal of trophoblast stem cells. ESSRB also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Defects in the gene can cause deafness, autosomal recessive, 35 (DFNB35).

Specifications

• Antigen: ESRRB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ESRRB
• Gene Alias: DFNB35; ERR beta-2; ERR2; Err-2; ERRb; ERRB2; ERRbeta; ERR-beta; ERRbeta-2; ESRL2; ESRRB; estrogen receptor related 2; estrogen receptor-like 2; estrogen related receptor beta; estrogen related receptor, beta; estrogen-related nuclear receptor beta; estrogen-related receptor beta; estrogen-related receptor, beta; Estrrb; NR3B2; nuclear receptor ERRB2; nuclear receptor subfamily 3 group B member 2; orphan nuclear receptor; steroid hormone receptor ERR2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100058699, 100760486, 2103
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: O95718
• Gene Symbols: ESRRB
• Immunogen: Synthetic 14 amino acid peptide from internal region of human ESRRB.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Monkey, Hamster, Horse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov