Estrogen Receptor Alpha Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-155-7763	100 μL

Catalog No. 50-155-7763 Supplier Bethyl Laboratories, Inc Supplier No. A300495A

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

Specifications

• Antigen: Estrogen Receptor Alpha
• Applications: ChIP sequencing (ChIP-seq), Immunohistochemistry, Immunoprecipitation
• Classification: Polyclonal
• Concentration: 1 mg/ml
• Conjugate: Unconjugated
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene: ESR1
• Gene Accession No.: P03372
• Gene Alias: ER
• Gene Symbols: ESR1
• Host Species: Rabbit
• Immunogen: Between 1 and 50
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2099
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG