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Estrogen Receptor Beta Mouse anti-Human, Clone: PPZ0506, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524807

Catalog No. PIMA524807


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Description

Description

This antibody specifically recognizes human ER beta but does not recognize human ER alpha.

Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms domitly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
Specifications

Specifications

Estrogen Receptor Beta
Monoclonal
1 mg/mL
physiological saline with 0.1% sodium azide
Q92731
ER Beta, ER, ESR2, ESR-Beta
Mouse
IgG2b
100 μL
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Primary
2100
ELISA, Immunoprecipitation, Western Blot
PPZ0506
Unconjugated
ESR2
Liquid
ESR2
Estrogen Receptor beta antibody for 2-88 amino acid peptide in human ER beta. Ligand for estrogenic 17b-estradiol compound.
Ammonium sulfate precipitation
RUO
Antibody
Monoclonal
Human
Documents
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