Invitrogen™ ESX1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562526

Catalog No. PIPA562526

Description

Immunogen sequence: HEPEQQQEEP PLLELKQEQE EPPQTTVEGP QPAEGPQTAE GPQPPERKRR RRTAFTQFQ Highest antigen sequence identity to the following orthologs: Mouse - 37%, Rat - 36%.

Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain. During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion and the labyrinthine trophoblast of the chorioallantoic placenta. ESX1 can act like a transcriptional repressor to the human oncogene K-ras and treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorgenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.

Specifications

• Antigen: ESX1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Esx1
• Gene Alias: ESX homeobox 1; ESX1; ESX1L; ESX1R; ESX1-related protein; ESXR1; extraembryonic spermatogenesis homeobox 1; extraembryonic, spermatogenesis, homeobox 1; extraembryonic, spermatogenesis, homeobox 1 homolog; homeobox protein ESX1; Homeobox protein ESX1-C; Homeobox protein ESX1-N; RP3-513M9.1; Spx1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80712
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8N693
• Gene Symbols: Esx1
• Immunogen: Recombinant protein corresponding to Human ESX1. Recombinant protein control fragment (Product #RP-100051).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG