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Invitrogen™ ESX1 Polyclonal Antibody
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Catalog No. PIPA562526
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100 μL
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PIPA562526 100 μL
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Catalog No. PIPA562526 Supplier Invitrogen™ Supplier No. PA562526
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HEPEQQQEEP PLLELKQEQE EPPQTTVEGP QPAEGPQTAE GPQPPERKRR RRTAFTQFQ Highest antigen sequence identity to the following orthologs: Mouse - 37%, Rat - 36%.

Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain. During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion and the labyrinthine trophoblast of the chorioallantoic placenta. ESX1 can act like a transcriptional repressor to the human oncogene K-ras and treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorgenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ESX1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Esx1
Gene Accession No. Q8N693
Gene Alias ESX homeobox 1; ESX1; ESX1L; ESX1R; ESX1-related protein; ESXR1; extraembryonic spermatogenesis homeobox 1; extraembryonic, spermatogenesis, homeobox 1; extraembryonic, spermatogenesis, homeobox 1 homolog; homeobox protein ESX1; Homeobox protein ESX1-C; Homeobox protein ESX1-N; RP3-513M9.1; Spx1
Gene Symbols Esx1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ESX1. Recombinant protein control fragment (Product #RP-100051).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 80712
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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