ETO / RUNX1T1 Polyclonal Antibody, Active Motif™

Catalog No.	Quantity
50-199-3150	10 μL
50-199-3149	100 μL

Catalog No. 50-199-3150 Supplier Active Motif Supplier No. 61110

Description

Rabbit Polyclonal Antibody

RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.

Specifications

• Antigen: ETO / RUNX1T1
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: Lot-Specific
• Conjugate: Unconjugated
• Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
• Gene: RUNX1T1
• Gene Accession No.: Q06455
• Gene Alias: acute myelogenous leukemia 1 translocation 1 protein; acute myelogenous leukemia 1 translocation 1, cyclin-D related; AML1-MTG8; AML1T1; BOS_14107; Cbfa2t1; CBFA2T1 identified gene homolog; CBFA2T1 isoform r1t1-11a61; CBFA2T1 isoform r1t1-11a62; CBFA2T1 isoform r1t1-11a63; CBFA2T1 isoform r1t1-11a64; CBFA2T1 isoform r1t1-11a65; CBFA2T1 isoform r1t1-7a47; CBFA2T1 isoform r1t1-7a48; CBFA2T1 isoform r1t1-7a49; CBFA2T1 isoform r1t1-7a50; CBFA2T1 isoform r1t1-7a51; CBFA2T1 isoform r1t1-7a52; CBFA2T1 isoform r1t1-7d53; CBFA2T1 isoform r1t1-7d54; CBFA2T1 isoform r1t1-7d55; CBFA2T1 isoform r1t1-7d56; CBFA2T1 isoform r1t1-8a57; CBFA2T1 isoform r1t1-8a58; CBFA2T1 isoform r1t1-8a59; CBFA2T1 isoform r1t1-8a60; Cbfa2t1h; CDR; core-binding factor, runt domain, alpha subunit 2, translocated to, 1; core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related; cyclin D-related; Cyclin-D-related protein; Eight twenty one protein; ETO; LOC100155449; LOC100354419; MGC2796; Mtg8; MTG8b; myeloid translocation gene on 8q22; Protein CBFA2T1; protein CBFA2T1-like; Protein ETO; Protein MTG8; runt related transcription factor 1; translocated to, 1 (cyclin D related); runt-related transcription factor 1; translocated to, 1 (cyclin D-related); RUNX1 translocation partner 1; RUNX1T1; si:ch211-232j17.1; translocated to, 1; wu:fi14b07; zgc:154044; Zinc finger MYND domain-containing protein 2; ZMYND2
• Gene Symbols: RUNX1T1
• Host Species: Rabbit
• Immunogen: This ETO / RUNX1T1 antibody was raised against a peptide within the internal region of human ETO / RUNX1T1.
• Purification Method: Antigen affinity chromatography
• Quantity: 10 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 862
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG