Ets-1 Polyclonal Antibody, Active Motif™

Catalog No.	Quantity
50-199-4064	10 μL
50-199-4063	200 μL

Catalog No. 50-199-4064 Supplier Active Motif Supplier No. 39581

Description

Rabbit Polyclonal Antibody

ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homlog 1 (avian); ETS-1; EWSR2; p54), a 441 A. A protein, is a member of DNA-binding ETS protein family. It is a multifunctional protein consisting of an N-terminal pointed domain, a central transactivation domain and 2 auto inhibitory domains flanked on both sides of conserved C-terminal Ets domain. It interacts with factors including PEBP2alphaA, p300/CBP and mediates transactivation of Osteopontin, Presenilin-1, Stromelysin and Collagenase. It is activated by Ras/MAPK signaling and its expression is up-regulated in resting T-cells. Its activity is modulated by various factors including AP-1, Sp-1, c-myb and MafB. Sp100 activates ETS1 in nuclear bodies. It interacts with EAP1/Daxx and causes repression of MMP1 and BCL2 transactivation. It interacts with STAT6 and modulates Socs-1 expression induced by IL-4. It interacts with GATA3 and positively regulates Tax-1 dependent IL-5 expression.

Specifications

• Antigen: Ets-1
• Applications: ChIP sequencing (ChIP-seq), Western Blot
• Classification: Polyclonal
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: whole serum with 30% glycerol and 0.035% sodium azide; pH
• Gene: ETS1
• Gene Accession No.: P14921
• Gene Alias: AI196000; AI448617; Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; avian erythroblastosis virus E26 oncogene 1; c-ets1; c-ets-1; c-ets-1 oncogene; D230050P06; E26 avian leukemia oncogene 1, 5' domain; Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1); ets protein; ETS proto-oncogene 1, transcription factor; Ets1; Ets-1; ETS-1A; ETS-1B; Ets-1Delta(III-VI); Etsoncb; EWSR2; FLJ10768; p54; p54 transcription factor; Protein C-ets-1; TNFAIP3 interacting protein 1; TNIP1; Tpl1; Transforming protein p54/c-ets-1; transforming protein p68/c-ets-1; tumor progression locus 1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene; v-ets erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); virion-associated nuclear-shuttling protein
• Gene Symbols: ETS1
• Host Species: Rabbit
• Immunogen: This Ets-1 antibody was raised against a peptide corresponding to the C-terminal half of mouse Ets-1.
• Quantity: 10 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2113
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG