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ETV4 Monoclonal Antibody (OTI1A10), TrueMAB™, OriGene

Mouse Monoclonal Antibody
Supplier: OriGene TA811405

Description
ETV4: ets variant gene 4 (E1A enhancer binding protein, E1AF), also known as PEA3. Several members of the Ets gene family are known to encode sequencespecific DNA binding proteins. These include mouse PU.1, mouse and human Ets-1, Drosophila E74, chicken and human Ets-2 and rat GABP-a. Each of these proteins recognizes similar motifs in DNA that share a centrally located 5′-GGAA-3′ element. For instance, PEA3 binds the motif 5′-AGGAAG-3′ (the PEA-3 motif), but does not bind to the sequence 5′-AGGAAC-3′, recognized by PU.1, although PU.1 binds equally well to both sequences. It appears thatall of the Ets proteins recognize the same central core sequence but that each protein interacts with unique sequences that flank this core. PEA3 is expressed at readily detectable levels in cells of epithelial and fibroblastic origin but is not expressed in hematopoietic cells. This is in contrast to other members of the Ets gene family, such as Ets-1, Ets-2 and Fli-1, each of whichis expressed primarily in cells of hematopoietic origin.Specifications
ETV4 | |
Monoclonal | |
1 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
P43268 | |
ETV4 | |
Human recombit protein fragment corresponding to amino acids 1-276 of human ETV4 produced in E.coli. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Western Blot | |
OTI1A10 | |
Unconjugated | |
ETV4 | |
E1A-F, E1AF, PEA3, PEAS3 | |
Mouse | |
Affinity Chromatography | |
RUO | |
2118 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
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