Invitrogen™ EVER2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520527

Catalog No. PIPA520527

Description

A suggested positive control is rat thymus tissue lysate. PA5-20527 can be used with blocking peptide PEP-0647.

Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc.

Specifications

• Antigen: EVER2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TMC8
• Gene Alias: epidermodysplasia verruciformis 2; epidermodysplasia verruciformis protein 2; Epidermodysplasia verruciformis protein 2 homolog; EV2; Ever2; EVIN2; mFLJ00400; Tmc8; transmembrane channel like 8; transmembrane channel-like 8; transmembrane channel-like gene family 8; transmembrane channel-like protein 8
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 147138, 217356, 688276
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q7TN58, Q8IU68
• Gene Symbols: TMC8
• Immunogen: An 18 amino acid peptide from near the amino terminus of human EVER2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov