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Invitrogen™ EVER2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599731

Catalog No. PIPA599731


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Description

Description

Antibody detects endogenous levels of total TMC8.

Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

EVER2
Polyclonal
Unconjugated
TMC8
epidermodysplasia verruciformis 2; epidermodysplasia verruciformis protein 2; Epidermodysplasia verruciformis protein 2 homolog; EV2; Ever2; EVIN2; mFLJ00400; Tmc8; transmembrane channel like 8; transmembrane channel-like 8; transmembrane channel-like gene family 8; transmembrane channel-like protein 8
Rabbit
Affinity chromatography
RUO
147138, 217356, 688276
-20°C
Liquid
Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q7TN58, Q8IU68
TMC8
A synthesized peptide derived from human TMC8(Accession Q8IU68), corresponding to amino acid residues S683-L726.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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