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Invitrogen™ EVER2 Polyclonal Antibody
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Catalog No. PIPA599731
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100 μL
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PIPA599731 100 μL
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Catalog No. PIPA599731 Supplier Invitrogen™ Supplier No. PA599731
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total TMC8.

Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EVER2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TMC8
Gene Accession No. Q7TN58, Q8IU68
Gene Alias epidermodysplasia verruciformis 2; epidermodysplasia verruciformis protein 2; Epidermodysplasia verruciformis protein 2 homolog; EV2; Ever2; EVIN2; mFLJ00400; Tmc8; transmembrane channel like 8; transmembrane channel-like 8; transmembrane channel-like gene family 8; transmembrane channel-like protein 8
Gene Symbols TMC8
Host Species Rabbit
Immunogen A synthesized peptide derived from human TMC8(Accession Q8IU68), corresponding to amino acid residues S683-L726.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 147138, 217356, 688276
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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