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Invitrogen™ EVER2 Polyclonal Antibody
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Catalog No. PIPA5111392
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100 μL
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PIPA5111392 100 μL
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Catalog No. PIPA5111392 Supplier Invitrogen™ Supplier No. PA5111392
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VQLENYPPNT EVNLTLIWCV VLKLASLGMF SVSLGQTILC IGRDKSSCES YGYNVCDYQC WENSVGEELY KLS Highest antigen sequence indentity to the following orthologs: Rat - 84%, Mouse - 89%.

Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EVER2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TMC8
Gene Accession No. Q8IU68
Gene Alias epidermodysplasia verruciformis 2; epidermodysplasia verruciformis protein 2; Epidermodysplasia verruciformis protein 2 homolog; EV2; Ever2; EVIN2; mFLJ00400; Tmc8; transmembrane channel like 8; transmembrane channel-like 8; transmembrane channel-like gene family 8; transmembrane channel-like protein 8
Gene Symbols TMC8
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human EVER2. Recombinant protein control fragment (Product #RP-91030).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 147138
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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