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  5. R&D Systems™ Evofosfamide

R&D Systems™ Evofosfamide
SDP

Catalog No. RD10195124 Shop All Novus Products
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RD10195124 10 mg
RD10195110 50 mg
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Catalog No. RD10195124 Supplier R&D Systems™ Supplier No. 7507/10

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Description

A Tocris product, part of R&D Systems. Hypoxia-activated DNA alkylating agent prodrug

Evofosfamide is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM). Evofosfamide is stable under normoxic conditions but is activated by cellular reductases in hypoxic conditions (IC50 values are 5.1 μM and 0.019 μM, in NSCLC cells under normoxic and hypoxic conditions, respectively). Br-IPM acts as a DNA alkylating agent, inducing intrastrand and interstrand crosslinks. Evofosfamide inhibits NEPC PDX tumor growth by 84.5% in adeno-CRPC and NEPC patient-derived xenograft models. When combined with gemcitabine (Cat. No. 3259), Evofosfamide inhibits primary tumor growth by 96% and significantly extends the survival time in the MIA PaCa-2 human pancreatic cancer orthotopic xenograft model.

Specifications

Chemical Name or Material (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)phosphorodiamidate
CAS 918633-87-1
Quantity 10 mg
Product Line Tocris
Target Apoptosis Inducer Compounds
Molecular Formula C9H16Br2N5O4P
Purity 0.98
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