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Tocris Bioscience™ Ex 26
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Catalog No. 583350 Shop All Novus Biologicals Products
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58-335-0 10 mg
58-331-0 50 mg
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Catalog No. 58-335-0 Supplier Tocris Bioscience™ Supplier No. 5833/50
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Description

Potent and selective S1P1 receptor antagonist

Ex 26 is a potent and selective S1P1 receptor antagonist (IC50 = 0.93 nM). Exhibits > 3,000-fold selectivity for S1P1 over S1P2, S1P3, S1P4 and S1P5. Induces lymphocyte sequestration in peripheral lymph nodes and upregulates S1P1 receptor expression. Reduces disease severity in mice with EAE. Increases IFN-α production in stimulated dendritic cells in vivo.

Specifications

Chemical Name or Material 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid
CAS 144678-63-7
Quantity 10 mg
Solubility Soluble to 100mM in DMSO and to 100mM in ethanol
Molecular Formula C28H28ClFN2O3
Formula Weight 494.98
Physical Form Solid
Color White
Product Type Bioactive Small Molecule
Purity >98%

For Research Use Only.

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