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EXD1 Monoclonal Antibody (OTI3H7), TrueMAB™, OriGene
SDP

Catalog No. 501673237
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50-167-3237 100 μL
50-254-1754 30 μL
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Catalog No. 50-167-3237 Supplier OriGene Supplier No. TA502158
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Description

Mouse Monoclonal Antibody

EXD1 is an RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.

Specifications

Antigen EXD1
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone OTI3H7
Concentration 0.73 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene EXD1
Gene Accession No. Q8NHP7
Gene Alias EXDL1
Gene Symbols EXD1
Host Species Mouse
Immunogen Full length human recombit protein of human EXD1 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 161829
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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