EXD1 Mouse anti-Human, Clone: OTI3E1, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF502101

Catalog No. 50-166-1038

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

EXD1 is an RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.

Specifications

• Antigen: EXD1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: EXD1
• Gene Alias: EXDL1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 161829
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Flow Cytometry, Western Blot
• Clone: OTI3E1
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q8NHP7
• Gene Symbols: EXD1
• Immunogen: Full length human recombit protein of human EXD1 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1