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EXD1 Mouse anti-Human, Rat, Clone: OTI2G5, lyophilized, TrueMAB™
SDP

Catalog No. 501661079
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100 μg
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50-166-1079 100 μg
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Catalog No. 50-166-1079 Supplier OriGene Supplier No. CF502147
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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

EXD1 is an RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.

Specifications

Antigen EXD1
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone OTI2G5
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene EXD1
Gene Accession No. Q8NHP7
Gene Alias EXDL1
Gene Symbols EXD1
Host Species Mouse
Immunogen Full length human recombit protein of human EXD1 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 161829, 311334
Target Species Human, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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