Invitrogen™ EXD2 Polyclonal Antibody

Catalog No.	Quantity
PIPA5113397	100 μg

Catalog No. PIPA5113397 Supplier Invitrogen™ Supplier No. PA5113397

Description

Rabbit Polyclonal Antibody

EXD2 Polyclonal Antibody for Western Blot, IHC (P), ELISA

Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528). Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466). Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466). [UniProt].

Specifications

• Antigen: EXD2
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 3.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene: EXD2
• Gene Accession No.: Q8VEG4, Q9NVH0
• Gene Alias: 3'-5' exoribonuclease EXD2; 4930539P14Rik; C14orf114; C85658; EXD2; EXDL2; exonuclease 3'-5' domain containing 2; exonuclease 3'-5' domain-containing protein 2; exonuclease 3''-5'' domain-like 2; exonuclease 3'-5' domain-like 2; exonuclease 3'-5' domain-like-containing protein 2; RGD1311087
• Gene Symbols: EXD2
• Host Species: Rabbit
• Immunogen: Recombinant Human Exonuclease 3'-5' domain-containing protein 2 protein (137-245AA).
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55218, 97827
• Target Species: Human, Mouse
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG