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Invitrogen™ EXOSC10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109699

Catalog No. PIPA5109699


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Description

Description

Immunogen sequence: VAAGVKKSGP LPSAERLENV LFGPHDCSHA PPDGYPIIPT SGSVPVQKQA SLFPDEKEDN LLGTTCLIAT AVITLFNEPS AEDSKKGPLT VAQKKAQNIM ESFENPFRMF LPSLGHRAPV SQAAKFDPST KIYEISNRWK LAQVQVQKDS KEAVKKKAAE QTAAREQAKE ACKAAAEQAI SVRQQVVLEN AAKKRERATS DPRTTEQKQE KKRLKISKKP KDPEPPEKEF TPYDYSQSDF KAFAGNSKSK VSSQFDPNKQ TPSGKKCIAA KKIKQSVGNK SMSFPTGKSD RGFRYNWPQR.

About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

EXOSC10
Polyclonal
Unconjugated
EXOSC10
Autoantigen PM/Scl 2; Autoantigen PM/Scl 2 homolog; autoantigen PM-SCL; Exosc10; Exosome component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; p2; p3; p4; PM/Scl-100; PMSCL; PM-Scl; PMSCL2; Polymyositis/scleroderma autoantigen 100 kDa; polymyositis/scleroderma autoantigen 2; Polymyositis/scleroderma autoantigen 2 homolog; RRP6; Rrp6p
Rabbit
Affinity Chromatography
RUO
313707, 50912, 5394
-20°C, Avoid Freeze/Thaw Cycles
Liquid
ELISA, Western Blot
1.73 mg/mL
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
P56960, Q01780
EXOSC10
Recombinant fusion protein containing a sequence corresponding to amino acids 586-885 of human EXOSC10 (NP_001001998.1).
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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