Invitrogen™ EXOSC10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109699

Catalog No. PIPA5109699

Description

Immunogen sequence: VAAGVKKSGP LPSAERLENV LFGPHDCSHA PPDGYPIIPT SGSVPVQKQA SLFPDEKEDN LLGTTCLIAT AVITLFNEPS AEDSKKGPLT VAQKKAQNIM ESFENPFRMF LPSLGHRAPV SQAAKFDPST KIYEISNRWK LAQVQVQKDS KEAVKKKAAE QTAAREQAKE ACKAAAEQAI SVRQQVVLEN AAKKRERATS DPRTTEQKQE KKRLKISKKP KDPEPPEKEF TPYDYSQSDF KAFAGNSKSK VSSQFDPNKQ TPSGKKCIAA KKIKQSVGNK SMSFPTGKSD RGFRYNWPQR.

About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.

Specifications

• Antigen: EXOSC10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EXOSC10
• Gene Alias: Autoantigen PM/Scl 2; Autoantigen PM/Scl 2 homolog; autoantigen PM-SCL; Exosc10; Exosome component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; p2; p3; p4; PM/Scl-100; PMSCL; PM-Scl; PMSCL2; Polymyositis/scleroderma autoantigen 100 kDa; polymyositis/scleroderma autoantigen 2; Polymyositis/scleroderma autoantigen 2 homolog; RRP6; Rrp6p
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 313707, 50912, 5394
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.73 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P56960, Q01780
• Gene Symbols: EXOSC10
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 586-885 of human EXOSC10 (NP_001001998.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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