Invitrogen™ EXOSC5 Polyclonal Antibody

Catalog No.	Quantity
PIPA565967	100 μL

Catalog No. PIPA565967 Supplier Invitrogen™ Supplier No. PA565967

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MEEETHTDAKI RAENGTGSSP RGPGCSLRHF ACEQNLLSRP DGSASFLQGD TSVLAGVYGP AEVKVSKEI Highest antigen sequence identity to the following orthologs - mouse 80%, rat 81%.

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. [UniProt].

Specifications

• Antigen: EXOSC5
• Applications: Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.05 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: EXOSC5
• Gene Accession No.: Q9NQT4
• Gene Alias: Chronic myelogenous leukemia tumor antigen 28; CML28; D7Wsu180e; EXOSC5; Exosome complex component RRP46; exosome complex exonuclease RRP46; exosome complex exonuclease RRP46; exosome complex component RRP46; exosome component 5; exosome component Rrp46; hRrp46p; p12B; Ribosomal RNA-processing protein 46; RRP41B; RRP46; Rrp46p; si:ch211-194n6.2; Unknown (protein for MGC:153707); zgc:153707
• Gene Symbols: EXOSC5
• Host Species: Rabbit
• Immunogen: Recombinant Human EXOSC5. Recombinant protein control fragment (Product #RP-106655).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 56915
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov