Invitrogen™ EXOSC6 Polyclonal Antibody

Catalog No.	Quantity
PIPA5107120	100 μL

Catalog No. PIPA5107120 Supplier Invitrogen™ Supplier No. PA5107120

Description

Rabbit Polyclonal Antibody

Sequence homology: Cow: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 86%.

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

Specifications

• Antigen: EXOSC6
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
• Gene: EXOSC6
• Gene Accession No.: Q5RKV6
• Gene Alias: 2610510N21Rik; C76919; EAP4; Exosc6; Exosome complex component MTR3; exosome complex exonuclease MTR3; exosome component 6; hMtr3; hMtr3p; homolog of yeast mRNA transport regulator 3; mRNA transport regulator 3; mRNA transport regulator 3 homolog; MTR3; Mtr3 (mRNA transport regulator 3)-homolog; Mtr3p; p11
• Gene Symbols: EXOSC6
• Host Species: Rabbit
• Immunogen: Synthetic peptide directed towards the N terminal region of human EXOSC6.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 118460
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG