Invitrogen™ EXOSC7 Monoclonal Antibody (2F10)

Catalog No.	Quantity
PIMA521390	100 μg

Catalog No. PIMA521390 Supplier Invitrogen™ Supplier No. MA521390

Description

Mouse Monoclonal Antibody

Peptide Sequence: LSVENVPCIV TLCKIGYRHV VDATLQEEAC SLASLLVSVT SKGVVTCMRK VGKGSLDPES IFEMMETGKR VGKVLHASLQ SVLHKEESLG PKRQKVGFLG.

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

Specifications

• Antigen: EXOSC7
• Applications: ELISA
• Classification: Monoclonal
• Clone: 2F10
• Concentration: 0.2-1.0 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative; pH 7.4
• Gene: EXOSC7
• Gene Accession No.: Q15024
• Gene Alias: 2610002K22Rik; AV212732; EAP1; EGK_11725; EXOSC7; Exosome complex component RRP42; exosome complex exonuclease RRP42; exosome complex exonuclease RRP42; exosome complex component RRP42; Exosome complex exonuclease RRP42-like protein; exosome component 7; hRrp42p; hypothetical protein LOC550247; KIAA0116; mKIAA0116; p8; Ribosomal RNA-processing protein 42; RRP42; Rrp42p; zgc:110717
• Gene Symbols: EXOSC7
• Host Species: Mouse
• Immunogen: EXOSC7 (NP_055819.1, 192 a.a. ~ 291 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23016
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a κ