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Invitrogen™ EXOSC7 Polyclonal Antibody
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Catalog No. PIPA541854
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100 μL
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PIPA541854 100 μL
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Catalog No. PIPA541854 Supplier Invitrogen™ Supplier No. PA541854
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Description

Rabbit Polyclonal Antibody

Peptide sequence: LEKPNEGYLE FFVDCSASAT PEFEGRGGDD LGTEIANTLY RIFNNKSSVD Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%.

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EXOSC7
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene EXOSC7
Gene Accession No. Q15024
Gene Alias 2610002K22Rik; AV212732; EAP1; EGK_11725; EXOSC7; Exosome complex component RRP42; exosome complex exonuclease RRP42; exosome complex exonuclease RRP42; exosome complex component RRP42; Exosome complex exonuclease RRP42-like protein; exosome component 7; hRrp42p; hypothetical protein LOC550247; KIAA0116; mKIAA0116; p8; Ribosomal RNA-processing protein 42; RRP42; Rrp42p; zgc:110717
Gene Symbols EXOSC7
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human EXOSC7 (aa 71-120).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23016
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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