Invitrogen™ EYA2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA568561

Catalog No. PIPA568561

Description

This target displays homology in the following species: Cow: 93%; Dog: 79%; Horse: 86%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 93%.

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.

Specifications

• Antigen: EYA2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EYA2
• Gene Alias: Drosophila-type eyes absent 2-like protein; Eab1; EYA transcriptional coactivator and phosphatase 2; Eya2; eyes absent 2; eyes absent 2 homolog; eyes absent 2 homolog (Drosophila); eyes absent 2 isoform a; eyes absent homolog 2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 156826
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: 0
• Gene Symbols: EYA2
• Immunogen: synthetic peptide directed towards the middle region of human EYA2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov