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EYA2 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501572626
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50-157-2626 10 μL
50-157-2625 100 μL
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Catalog No. 50-157-2626 Supplier Bethyl Laboratories, Inc Supplier No. IHC00736T
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Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Bovine, Horse, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, Little brow

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates ′Tyr- 142′ of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. ′Tyr-142′ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.

Specifications

Antigen EYA2
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene EYA2
Gene Accession No. O00167
Gene Alias Eyes absent homolog 2, EYA2, EAB1
Gene Symbols EYA2
Host Species Rabbit
Immunogen Between 100 and 150
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2139
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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