EZH2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA529129

Catalog No. PIPA529129

Description

Recommended positive controls: H1299, HCT116, MCF-7. Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (94%), Japanese Medaka (95%), Xenopus laevis (97%), Pig (99%), Rhesus Monkey (100%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

EZH2 (Histone-lysine N-methyltransferase) is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems. Mutations affecting EZH2 can cause Weaver syndrome (WVS).

Specifications

• Antigen: EZH2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EZH2
• Gene Alias: an; enhancer of zeste 2 polycomb repressive complex 2 subunit; enhancer of zeste homolog 2; enhancer of zeste homolog 2 (Drosophila); ENX 1; ENX1; Enx-1; Enx1h; EZH 2; EZH1; EZH2; EZH-2; EZH2b; histone-lysine N-methyltransferase EZH2; KMT6; KMT6A; lysine N-methyltransferase 6; mKIAA4065; OTTHUMP00000213774; OTTHUMP00000213778; OTTHUMP00000213779; OTTHUMP00000213780; WVS; WVS2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2146
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ChIP Assay, Immunocytochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q15910
• Gene Symbols: EZH2
• Immunogen: Recombinant fragment corresponding to a region within amino acids 385 and 664 of Human EZH2/KMT6
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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