F12 Monoclonal Antibody (OTI2D12), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-1443	100 μL

Catalog No. 50-168-1443 Supplier OriGene Supplier No. TA807225

Description

Mouse Monoclonal Antibody

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI.

Specifications

• Antigen: F12
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI2D12
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: F12
• Gene Accession No.: P00748
• Gene Alias: HAE3, HAEX, HAF
• Gene Symbols: F12
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 73-372 of human F12 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2161
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1