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F13A1 Monoclonal Antibody (OTI8E2), TrueMAB™, OriGene

Mouse Monoclonal Antibody
Supplier: OriGene TA800393

Description
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.Specifications
F13A1 | |
Monoclonal | |
Unconjugated | |
F13A1 | |
F13A | |
Mouse | |
Affinity Chromatography | |
RUO | |
2162 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot | |
OTI8E2 | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
P00488 | |
F13A1 | |
Full length human recombit protein of human F13A1 produced in HEK293T cell. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG2b |
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