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F13A1 Monoclonal Antibody (OTI8E2), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA800393

Encompass_Preferred

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Catalog No. 50-167-8291


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Description

Description

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
Specifications

Specifications

F13A1
Monoclonal
Unconjugated
F13A1
F13A
Mouse
Affinity Chromatography
RUO
2162
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
OTI8E2
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P00488
F13A1
Full length human recombit protein of human F13A1 produced in HEK293T cell.
100 μL
Primary
Human
Antibody
IgG2b
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