F13A1 Mouse anti-Human, Clone: OTI9E2, liquid, TrueMAB™

Catalog No.	Quantity
50-167-7177	100 μg

Catalog No. 50-167-7177 Supplier OriGene Supplier No. TA600092

Description

Mouse Monoclonal Antibody

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

Specifications

• Antigen: F13A1
• Applications: ELISA
• Classification: Monoclonal
• Clone: OTI9E2
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with <5% trehalose and 0.05% sodium azide
• Gene: F13A1
• Gene Accession No.: P00488
• Gene Alias: F13A
• Gene Symbols: F13A1
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human F13A1 produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2162
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1