Invitrogen™ F1A alpha Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA519955

Catalog No. PIPA519955

Description

In Western blot applications, this antibody detects a band at ~70kDa. A suggested positive control is mouse liver tissue lysate. PA5-19955 can be used with blocking peptide PEP-0080.

Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1-b. F1Aalpha/FEM1-b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aalpha is cleaved by CED-3 and caspase. FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues.

Specifications

• Antigen: F1A alpha
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FEM1B
• Gene Alias: DKFZp451E0710; F1aa; F1A-alpha; fem-1 homolog B; fem-1 homolog b (C. elegans); Fem1b; FEM1-beta; FEM-1-like death receptor binding protein; fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; feminization 1 homolog b; feminization 1 homolog b (C. elegans); FIAA; Kiaa0396; mKIAA0396; mt-Fem; Protein fem-1 homolog B
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10116, 14155, 315745
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P0C6P7, Q9UK73, Q9Z2G0
• Gene Symbols: FEM1B
• Immunogen: A 14 amino acid peptide near the carboxy terminus of human F1A. The immunogen is located within the last 50 amino acids of F1A alpha.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov