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Invitrogen™ F1A alpha Polyclonal Antibody
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Catalog No. PIPA519955
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100 μg
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PIPA519955 100 μg
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Catalog No. PIPA519955 Supplier Invitrogen™ Supplier No. PA519955
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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~70kDa. A suggested positive control is mouse liver tissue lysate. PA5-19955 can be used with blocking peptide PEP-0080.

Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1-b. F1Aalpha/FEM1-b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aalpha is cleaved by CED-3 and caspase. FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen F1A alpha
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene FEM1B
Gene Accession No. P0C6P7, Q9UK73, Q9Z2G0
Gene Alias DKFZp451E0710; F1aa; F1A-alpha; fem-1 homolog B; fem-1 homolog b (C. elegans); Fem1b; FEM1-beta; FEM-1-like death receptor binding protein; fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; feminization 1 homolog b; feminization 1 homolog b (C. elegans); FIAA; Kiaa0396; mKIAA0396; mt-Fem; Protein fem-1 homolog B
Gene Symbols FEM1B
Host Species Rabbit
Immunogen A 14 amino acid peptide near the carboxy terminus of human F1A. The immunogen is located within the last 50 amino acids of F1A alpha.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10116, 14155, 315745
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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