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F4/80 Rat anti-Mouse, Alexa Fluor® 647, Clone: BM8, Invitrogen™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MF48021

Catalog No. 50-113-8118


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Description

Description

F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.
Specifications

Specifications

F4/80, F4/80
Monoclonal
0.2 mg/mL
PBS with 4mg/mL BSA and 0.1% sodium azide
Q61549
EMR1, EMR1 hormone receptor, F4/80, EGF-like module receptor 1, TM7LN3
Rat
IgG2a
1 mL
4° C
Primary
13733
Flow Cytometry
BM8
Alexa Fluor® 647
Adgre1
Liquid
Adgre1
mouse F4/80 which is a macrophage-restricted cell surface glycoprotein.
Purified
RUO
Antibody
Monoclonal
Mouse
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