Invitrogen™ Factor X/Xa Monoclonal Antibody (5050)

Catalog No.	Quantity
MA143013	100 μg

Catalog No. MA143013 Supplier Invitrogen™ Supplier No. MA143013

Description

Mouse Monoclonal Antibody

This antibody detects the heavy chains of human factor Xa and X; does not bind bovine factor X or BEGRck-Xa. Does not recognize murine or porcine X via Western blot. Inhibitory properties: inhibits PT, prothrombinase and partially APTT, but not amidase activity. Purity >95% by SDS-PAGE.

Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.

Specifications

• Antigen: Factor X/Xa
• Applications: Affinity Purification, Inhibition Assays, Inhibition Assays, Radioimmune Assays (RIA), Western Blot
• Classification: Monoclonal
• Clone: 5050
• Concentration: 7.6 mg/mL
• Conjugate: Unconjugated
• Formulation: 50% water with 50% glycerol and no preservative
• Gene: F10
• Gene Accession No.: P00742
• Gene Alias: Activated factor Xa heavy chain; blood coagulation factor X; Cf10; coagulation factor 10; coagulation factor X; coagulation factor X protein; F10; Factor X heavy chain; Factor X light chain; factor Xa; FX; FXA; prothrombinase; stuart factor; Stuart-Prower factor; Unknown (protein for IMAGE:8121240); unnamed protein product
• Gene Symbols: F10
• Host Species: Mouse
• Immunogen: Purified human Factor X.
• Purification Method: SDS-PAGE
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2159
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1