Invitrogen™ Factor XI Monoclonal Antibody (5061)

Catalog No.	Quantity
MA143021	100 μg

Catalog No. MA143021 Supplier Invitrogen™ Supplier No. MA143021

Description

Mouse Monoclonal Antibody

MA1-43021 detects Factor XI in human samples. MA1-43021 has successfully been used in western blot (non-reducing) and radioimmunoassays applications. MA1-43021 was derived from human factor XI.

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.

Specifications

• Antigen: Factor XI
• Applications: ELISA, Inhibition Assays, Radioimmune Assays (RIA), Western Blot
• Classification: Monoclonal
• Clone: 5061
• Concentration: 9.4 mg/mL
• Conjugate: Unconjugated
• Formulation: 50% water with 50% glycerol and no preservative
• Gene: F11
• Gene Accession No.: P03951
• Gene Alias: 1600027G01Rik; AI503996; Cf11; Coagulation factor XI; Coagulation factor XIa heavy chain; Coagulation factor XIa light chain; F11; FXI; LRRGT00086; plasma thromboplastin antecedent; PTA
• Gene Symbols: F11
• Host Species: Mouse
• Immunogen: Human factor XI.
• Purification Method: SDS-PAGE
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2160
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG