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Invitrogen™ Factor XI Polyclonal Antibody
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Catalog No. PA143048
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PA143048 1 mg
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Catalog No. PA143048 Supplier Invitrogen™ Supplier No. PA143048
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Description

Sheep Polyclonal Antibody

PA1-43048 detects Factor XI in human samples. PA1-43048 has successfully been used in Western blot and ELISA applications. PA1-43048 was derived from human factor XI.

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Factor XI
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 12.4 mg/mL
Conjugate Unconjugated
Formulation 50% water with 50% glycerol and no preservative
Gene F11
Gene Accession No. P03951
Gene Alias 1600027G01Rik; AI503996; Cf11; Coagulation factor XI; Coagulation factor XIa heavy chain; Coagulation factor XIa light chain; F11; FXI; LRRGT00086; plasma thromboplastin antecedent; PTA
Gene Symbols F11
Host Species Sheep
Immunogen Human Factor XI.
Purification Method SDS-PAGE
Quantity 1 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2160
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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